Arnold S. Leonard Cancer Research Fund

Arnold S. Leonard, M.D., Ph.D.

Dr. Leonard was Professor of Surgery at the University of Minnesota and Head of the Pediatric Surgery Department. He has devoted himself entirely to cancer research in genetic engineering, boosting the immune system with human interleukin-2 gene. An Endowed Scholar Chair has been placed in Dr. Leonard’s name in the Surgery Department at the University of Minnesota, and he has also received the Wangensteen Award for Academic Excellence. Dr. Leonard belongs to the major surgical societies, and continues to lecture throughout the world on the importance of the immune system and its relationship to cancer. He has written over 260 articles and books.

Arnold S. Leonard, M.D., Ph.D.

2015 Lab Update

Your contributions over the past year have provided the Saltzman laboratory with funds to carry out the following important experiments that the lab personnel have optimistically named:

“The Home Run”

  1. To the lab’s original genetic engineered construct (stimulating the body’s immune system by a protein that releases cells that kill cancer), they have now entered into the tumor itself to evaluate the mechanisms which fuel the increase in cancer size.
  1. Most importantly, the lab has evaluated 2 genes in tumors that work against the immune system, and antibodies against these genes have been made and are being tested.
  1. Because tumors have an intricate vascular system that contributes to the growth of the tumor, the lab has added an antivascular vessel factor to their genetic construct, along with the antibodies mentioned above to combat the tumor growth system.
  1. The U of MN Veterinary School has also conducted experiments using the lab’s original genetic engineered construct against Osteogenic Sarcoma, the worst bone tumor in long bone dogs (and teenage humans). The results so far have been encouraging.
  1. By adding the antibodies, the antivascular factor, and another protein to the original construct, we are looking forward to another productive year in the Saltzman lab, fighting this most discouraging disease. Thank you for your confidence and support.

IMG_1437 copy2014 Bioengineering Lab Update

As they learn more about how cancers develop and spread, the bioengineering cancer research lab at the University of Minnesota has focused on the tumor microenvironment where cancers can grow and flourish.

Using genetically altered Salmonella to deliver a cocktail of immune modulating proteins right to a cancerous tumor (into the tumor microenvironment), the immune system is stimulated to make cancer killing immune cells.

In addition, the lab uses engineered salmonella to carry proteins that block the cancer’s ability to suppress the immune system.

Thus, they are altering the cancer’s microenvironment by simultaneously stimulating the immune system to kill cancer and stop the cancer cell’s ability to spread and grow.

The lab still needs to determine how much and how often to give the Salmonella, and if there is a different combination that would be more effective.

Also, the FDA will require several studies once the lab determines which combination is most effective for the Investigational New Drug (IND) application.

Funds are currently being used to study a variety of cancer types.

Thank you to our generous supporters!

Over the past 8 years, YOU and this generous community of private and corporate sponsors have donated over 2 million dollars to ASL Cancer Research Fund to help us put cancer on the run, with thousands of people from the hunting community participating in the hunting fundraisers during this same time period.

Dr. Leonard continues to raise funds for the Saltzman lab at the University of Minnesota and attends weekly lab meetings with the team of Doctors, Scientists and Volunteers working on this cutting edge cancer research that Dr. Leonard began over 20 years ago. He also teaches classes in 4 subjects to University of Minnesota Medical School students, and is involved in a number of philanthropic organizations. Dr. Leonard continues to enjoy gardening his championship Dahlias, hunting traveling, his growing number of great grandchildren, and attending University of Minnesota alumni events.

Donation Acknowledgements

Did you know that when you donate to the ASL Cancer Research Fund, you can make your donation in honor of someone, or in memory of someone, and we will send them or their family a nice acknowledgement letter personally signed by Dr. Leonard stating who the donation was given by? This is a great way to help fund our cutting edge cancer research, create a tax deduction for yourself, while giving a unique gift to a special person in your life. Just add a note to your donation stating the name, address, and message for the person in whose honor/memory you are donating, and we will take care of the rest.

Dr. Leonard signing books at the Amplatz Children’s Hospital

Click here for a great video explaining the genetic engineering in the lab:

Dr. Leonard’s New Book

“Through the Portals of Pigs and Manure, The Story of the Minnesota Influence on American Surgery”


Dr. Leonard’s book is now available and can be purchased here for $14.99. All proceeds from the sale of this book will benefit the Arnold S. Leonard Cancer Research Fund.

$14.99, pay via PayPal

Check out the book’s facebook page
for more info, stories and photos.

Note: If you wish to purchase more than a dozen books, or if you want to submit payment by check, please contact our office at 612-280-6244.


What’s Inside

  • Owen Wangensteen and John Najarian and their Academic Training Program
  • The Mayo Clinic Relationship with the University of Minnesota Medical School
  • The Origin of Open Heart Surgery
  • The Origin of the Pacemaker
  • Intestinal Obstruction Suction Devices
  • The Ulcer Problem
  • The Cancer Detection Center
  • Transplantation – John Najarian et. al.
  • The Pediatric Surgery Division
  • The Colo-Rectal Division
  • The Morbid Obesity Problem
  • Whale Surgery with the Minnesota Zoo

Mission Statement

The Arnold S. Leonard Cancer Research Fund raises funds to directly support cancer research in genetic engineering taking place at the University of Minnesota bioengineering lab.

Alumni Philanthropy and Service Award

It was quite inspirational seeing Dr. Leonard acknowledged among the most influential University of Minnesota Medical School alumni October 15th, 2010. The University of Minnesota Medical Alumni Society hosted the Alumni Celebration Banquet where Dr. Leonard was awarded with the Alumni Philanthropy and Service Award, in honor of his significant medical and philanthropic contributions to the Medical School, the University and the community.

Dr. Leonard and Dr. Saltzman Honored

The Arnold S. Leonard, M.D., Ph.D. Chair in Pediatric Surgery was established in 2004 as a permanent source of funding to enhance the teaching, clinical work, and research of Dr. Leonard. Endowed Scholar and Honoree honors were given to Dr. Saltzman and Dr. Leonard by the University of Minnesota.